Comparison of the reinforcing properties of
cocaine and procaine in rhesus monkeys

Johanson CE, Aigner T
Pharmacol Biochem Behav 1981 Jul; 15(1):49-53


Previous studies have shown that a variety of local anesthetics including procaine are self-administered at high rates by rhesus monkeys. In the present study two rhesus monkeys were given a mutually exclusive choice between various doses of intravenous cocaine and procaine. In almost all comparisons cocaine was preferred even when the procaine dose was 16 times that of cocaine. Other measures of performance such as rate of responding did not vary systematically with preference. These data provide further support for the idea that rate of responding under simple schedules of drug delivery is an unreliable measure of relative reinforcing efficacy. In addition, the consistent preference for cocaine over procaine in monkeys suggests that the infrequent abuse of procaine by humans may be related to its low reinforcing efficacy relative to drugs such as cocaine.

Prenatal cocaine
Dopaminergic flies?
Dopaminergic agents
Cocaine immunization
The coke-craving brain
Cocaine and the lonely rat
Monoamines, cocaine and rats
Freebasing flies go hyperkinetic

01 02 03 04 05 06 07 08 09 10 11 12
13 14 15 16 17 18 19 20 21 22 23 24

Future Opioids
BLTC Research
Wirehead Hedonism
Utopian Pharmacology
The Hedonistic Imperative
When Is It Best to Take Crack Cocaine?

swan image
The Good Drug Guide
The Responsible Parent's Guide To
Healthy Mood Boosters For All The Family