Regulation of opioid receptors by cocaine
Unterwald EM.
Department of Pharmacology,
Temple University School of Medicine,
3420 N. Broad Street,
Philadelphia, PA 19140, USA.
Ann N Y Acad Sci 2001 Jun; 937:74-92


Cocaine is a widely abused psychostimulant. Its direct actions include inhibition of dopamine, serotonin, and norepinephrine reuptake into presynaptic nerve terminals, thereby potentiating the actions of these transmitters in the synapse. A variety of studies have demonstrated that cocaine can also have profound effects on the endogenous opioid system. Compelling evidence points to the importance of mu opioid receptors in human cocaine addiction and craving. Animal studies support these findings and demonstrate that chronic cocaine administration can result in alterations in opioid receptor expression and function as measured by changes in critical signal transduction pathways. This chapter reviews studies on the regulation of opioid receptors as the result of exposure to cocaine.

Inca tea
Oral cocaine
The coke-craving brain
Cocaine and depression
Cocaine and the lonely rat
Cocaine and mu opioid receptors
Cocaine, dopamine d2 receptors and mu opioid receptors

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Future Opioids
BLTC Research
Wirehead Hedonism
Utopian Pharmacology
The Hedonistic Imperative
When Is It Best to Take Crack Cocaine?

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