Glutamatergic Agents for Cocaine Dependence
Dackis C, O'Brien C.
Treatment Research Center, University of Pennsylvania,
3900 Chestnut Street, Philadelphia, Pennsylvania 19104, USA.
Ann N Y Acad Sci. 2003 Nov;1003:328-345
ABSTRACTEffective medications for cocaine dependence are needed to improve outcome in this chronic, relapsing disorder. Medications affecting glutamate function are reasonable candidates for investigation, given the involvement of glutamate circuits in reward-related brain regions and evdence of cocaine-induced glutamatergic dysregulation. In addition, it is increasingly apparent that glutamatergic mechanisms underlie several clinical aspects of cocaine dependence, including euphoria, withdrawal, craving, and hedonic dysfunction. Even denial, traditionally viewed as purely psychological, may result, in part, from dysfunctional glutamate-rich cortical regions. We review the involvement of glutamate in reward-related circuits, the acute and chronic effects of cocaine on these pathways, and glutamatergic mechanisms that contribute to the neurobiology of cocaine dependence. We also present preliminary data from our research of modafinil, a glutamate-enhancing agent with promise in the treatment of cocaine-addicted individuals.NR2B
The coke-craving brain
Monoamines, cocaine and rats
Freebasing flies go hyperkinetic
Glutamate, dopamine and cocaine addiction
Glutamate receptor antagonism reduces cocaine-seeking
01 02 03 04 05 06 07 08 09 10 11 12
13 14 15 16 17 18 19 20 21 22 23 24
The Hedonistic Imperative
When Is It Best to Take Crack Cocaine?
The Good Drug Guide
The Responsible Parent's Guide To
Healthy Mood Boosters For All The Family