Antagonism of cocaine's pharmacological effects by the stimulant dopaminergic antagonists, (+)-AJ76 and (+)-UH232
by
Piercey MF, Lum JT, Hoffmann WE,
Carlsson A, Ljung E, Svensson K
Upjohn Co., Kalamazoo, MI 49001.
Brain Res 1992 Aug 21;588(2):217-22


ABSTRACT

The aminotetralins (+)-AJ76 and (+)-UH232 are stimulant dopaminergic antagonists, which may preferentially antagonize autoreceptors of dopamine nerve terminals. Both agents antagonized cocaine's depressant effects on firing rates of ventral tegmental dopaminergic neurons, but (+)-UH232 was much more potent. When injected simultaneously with cocaine, (+)-UH232 inhibited and (+)-AJ76 enhanced the locomotor stimulation observed during the first 30 min following s.c. cocaine administration. However, (+)-AJ76 antagonized cocaine-induced stereotypies as well as the later more intense cocaine locomotor stimulation. It is suggested that preferential dopamine autoreceptor antagonists may provide a novel approach to a pharmacotherapy for treating cocaine abuse.


GBR12909
Acupuncture
Cocaine hotspots
Dopaminergic flies?
Dopaminergic agents
The coke-craving brain
Monoamines, cocaine and rats
GBR12909 and normal subjects
Freebasing flies go hyperkinetic
GBR12909: a dopaminergic antidepressant?

01 02 03 04 05 06 07 08 09 10 11 12
13 14 15 16 17 18 19 20 21 22 23 24


MORE
HedWeb
HerbWeb
BLTC Research
Wirehead Hedonism
Paradise-Engineering
Utopian Pharmacology
The Hedonistic Imperative
When Is It Best to Take Crack Cocaine?

swan image
The Good Drug Guide
The Responsible Parent's Guide To
Healthy Mood Boosters For All The Family